Protein Details: Neuronal acetylcholine receptor subunit alpha-9

Protein ID

ICDB_Pro_0528

Protein Name

Neuronal acetylcholine receptor subunit alpha-9

Gene Name

Chrna9; Acra9

Organism

Rattus norvegicus (Rat)

Length

479 amino acids

AlphaFoldDB

AF-P43144-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Sequence

MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1006/geno.1998.5363; 10.1007/bf02736842; 10.1016/s0014-5793(96)01383-x; 10.1038/ng1285; 10.1038/nature04601; 10.1101/gr.2596504; 10.1006/geno.1994.1075; 10.1006/geno.2002.6694; 10.1021/bi048918g; 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h; 10.1074/jbc.m410039200; 10.1124/mol.105.017459; 10.1111/jnc.13718; 10.1177/1087057116676086; 10.1016/j.celrep.2020.108025

RefSeq

NP_000737.1 [P36544-1]; NP_001177384.1 [P36544-2]; NP_683709.1; XP_005254807.1; XP_016877373.1